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Tsinghua Science and Technology

Keywords

disease-gene network, principal component analysis, community detection

Abstract

The identification of communities is imperative in the understanding of network structures and functions. Using community detection algorithms in biological networks, the community structure of biological networks can be determined, which is helpful in analyzing the topological structures and predicting the behaviors of biological networks. In this paper, we analyze the diseasome network using a new method called disease-gene network detecting algorithm based on principal component analysis, which can be used to investigate the connection between nodes within the same group. Experimental results on real-world networks have demonstrated that our algorithm is more efficient in detecting community structures when compared with other well-known results.

Publisher

Tsinghua University Press

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